منابع مشابه
Arginine vasopressin in heart failure.
Pathogenesis of AVP Release In several animal models of low-output and high-output cardiac failure and in congestive heart failure in humans, it has been demonstrated that plasma AVP, renin activity, aldosterone and norepinephrine are significantly increased.7 Renal excretion of sodium and water is predominantly regulated by the integrity of the arterial circulation, which is determined by card...
متن کاملVasopressin antagonism in heart failure.
Treatment of chronic heart failure (HF) is based on interference with the renin-angiotensin-aldosterone system and the adrenergic nervous system. Diuretics are used in volume-expanded patients. Insights from clinical trials and registries establish the need to consider correcting both cardiac loading conditions and nonload-related biological factors if HF therapy is to be optimized. Arginine va...
متن کاملVasopressin receptor antagonists in heart failure.
Vasopressin receptor antagonists are a new class of drugs that address the problems of fluid retention, hyponatremia, and renal dysfunction in heart failure. Elevated vasopressin levels in heart failure cause myocardial fibrosis, hypertrophy and vasoconstriction by activating the V1a receptors, as well as water retention and hyponatremia by activating V2 receptors. Antagonism of V1a receptors a...
متن کاملArginine Vasopressin Receptor Antagonists for Heart Failure
eart failure (HF) is among the most common causes of ospitalization, and its incidence will likely increase in an ging population of “survivors” (1). Pharmacological treatent targeted at neurohormonal activation has improved urvival, but mortality remains substantial in patients with F, thus warranting the search for novel therapeutic aproaches. Novel agents under investigation for the treatent...
متن کاملTherapeutic potential of vasopressin-receptor antagonists in heart failure.
Arginine vasopressin (AVP) is a 9-amino acid peptide that is secreted from the posterior pituitary in response to high plasma osmolality and hypotension. AVP has important roles in circulatory and water homoeostasis, which are mediated by oxytocin receptors and by AVP receptor subtypes: V(1a) (mainly vascular), V(1b) (pituitary), and V(2) (renal). Vaptans are orally and intravenously active non...
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ژورنال
عنوان ژورنال: Expert Review of Cardiovascular Therapy
سال: 2013
ISSN: 1477-9072,1744-8344
DOI: 10.1586/14779072.2013.839203